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The biological roles proposed for GHK-Cu in the research literature have included effects on collagen and extracellular matrix synthesis (through copper-dependent enzymes including lysyl oxidase), on antioxidant gene networks (where copper participates in both prooxidant and antioxidant chemistry depending on context), on growth factor activity in tissue repair, on hair follicle biology, and on broader transcriptional programs characterized in microarray and RNA-seq studies

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Furthermore, the glycine biosensor should be optimised to detect lower glycine concentrations at an earlier time

92,93 Advances in neurophysiological assessments, such as nerve conduction studies (NCS), have improved the detection of large fiber involvement in DN