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Vitamin B6: Though some research suggests vitamin B6 could help alleviate some of the emotional symptoms of PMDD, the small amount in this supplement is most likely added to help the body better metabolize the supplemental 5-HTP into serotonin.64 65 Lions mane: While research is still emerging, lions mane may help support mood and reduce inflammation.66 The amount included here is relatively modest compared to doses used in clinical studies, so it likely plays more of a supporting role in the formula

Reports of stability in gastric juice are not the same as systemic bioavailability, and routes of administration in published rodent work include intraperitoneal, oral (drinking water), and topical comparisons across routes are not always controlled in primary studies (Cerovecki et al., 2010)

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