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Dancing from bottoms uproles of the POZ-ZF transcription factor Kaiso in cancer

If done efficiently, it could explain the lack of a significant elevation in endogenous H 2 O 2 concentrations in parkin-deficient brain under steady-state conditions

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To evaluate the effects of variants in the LIR flanking region, as well as to test the limit of the MDS approach in capturing smaller changes in binding affinity, we assessed the M183A substitution, which is predicted to destabilize the interaction for both the phosphorylated and unphosphorylated variants of OPTN with approximately 2 kcal/mol