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After ferroptosis, excess intracellular free iron can enter the mitochondria, resulting in smaller myocardial mitochondria, increased mitochondrial membrane density, decreased mitochondrial respiration, and mitochondrial membrane potential depolarization (Sumneang et al., 2020), thus inducing CD and a series of Cardiac Diseases such as arrhythmia (Hu et al., 2021)

In virotherapy, NSC-mediated delivery of glioma-restricted adenoviruses (CRAd-S-pk7) enhances viral distribution while reducing immune clearance, demonstrating significant survival benefits in clinical trials

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Because excess age-related iron elevation in somatic tissue, particularly in brain (Massie et al., 1983