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The activation of JA-signaling pathways by SYS and HypSys can indirectly enhance resilience to oxidative stress, as JA-responsive genes like glutathione S-transferase ( GST ) contribute to detoxification and attenuation of oxidative damage ( HSPs ) in SYS- or PS-treated plants under biotic stress conditions suggests a potential overlap with abiotic stress responses, as HSPs stabilize proteins under various stresses (ul Haq et al., 2019)

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berghei blood stages can grow and develop in vivo in spite of low levels of intracellular GSH Given that -GCS catalyzes the rate-limiting step in GSH de novo biosynthesis, we predicted that disruption of the pbggcs locus would abolish parasite GSH levels

ONC finalized the HTI-1 final rule (89 FR 1192), effective March 11, 2024, to further implement the 21st Century Cures Act, among other policy goals