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It typically develops on chronically sun-exposed areas like the face, neck, and nose, often appearing as a pearly bump, a pink patch, or a sore that bleeds and wont fully heal

This is what activates melanocortin receptors in the body

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Subgroups are IIA, IIB, IIC Stage II melanoma is defined by tumor thickness (Breslow Depth) and ulceration There is no spread to nearby lymph nodes or distant sites Risk: intermediate to high for regional or distant spread Characteristics of Stage II Melanoma Stage II melanomas are defined by two primary characteristics: tumor thickness and ulceration