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There is a large microbial community in the human gut, and at least 20% of small molecules in the human blood are products of the microbiome, which plays a vital role in our physiology and metabolism (Rook et al., 2017)

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J Chromatogr 613:203221 Matsumoto K, Takahashi M, Takiyama N, Misaki H, Matsuo N, Murano S, Yuki H (1993) Enzyme reactor for urinary acylcarnitines assay by reversed-phase high-performance liquid chromatography