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[16] History, society and culture [edit] "Aphthous affectations" and "aphthous ulcerations" of the mouth are mentioned several times in the treatise "Of the Epidemics" (part of the Hippocratic corpus, in the 4th century BCE), [25] although it seems likely that this was oral ulceration as a manifestation of some infectious disease, since they are described as occurring in epidemic-like patterns, with concurrent symptoms such as fever

They determined a lowest observed adverse effect level for local irritant effects on the upper respiratory tract of 1,000 mg/m 3

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Canadian Classics History : Introduced by Rothmans, Benson & Hedges (RBH) in the late 20th century