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Fecal transplantation experiments revealed that when mice were infected with stool from NAFLD patients they developed hypertriglyceridemia in the liver and developed liver steatosis and change of gut microbes are implicated in NAFLD (Hoyles et al., 2018), the end products of saccharolytic and proteolytic fermentation by the gut microbiota (GM) are believed to influence the gut-liver axis and can directly impact the pathogenesis of non-alcoholic fatty liver disease (NAFLD)

References 1 Circulation Research (PubMed)SS-31 (elamipretide) binds cardiolipin in the inner mitochondrial membrane and stabilizes cristae structure

Logan, BR

Bouchard, C., Marquardt, J., Brs, A., Medema, R