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In addition, artesunate can enhance the antioxidant defense system and prevent oxidative damage in the lungs by inhibiting the PI3K and p42/22 MAPK signaling pathways, decreasing the levels of oxidative biomarkers (8-IPS, 8-OHdG, and 3-NT), promoting anti-hydrogen peroxide dismutase activity in lung tissues, and decreasing the expression of NADPH (Ng et al., 2014)