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Oct 6 2021;22(19)doi:10.3390/ijms221910822

Kawabori, M., Shichinohe, H., Kuroda, S

If detumescence has not been achieved after aspiration and irrigation with NS: Inject 100 mcg of phenylephrine (1 mL at 100 mcg/mL) q 3 to 5 min for up to 1 hour (ceiling dose is 1000 mcg) in between aspirations, OR Irrigate with diluted phenylephrine at 20 mcg/mL (20 mg of phenylephrine in 1 L of NS)

But arbutin in its raw form is not very effective and stable, which is why Minimalist Alpha Arbutin 2% serum uses Arbutin in its stable form - Alpha Arbutin, which is glycosylated Hydroquinone, a pure water-soluble, biosynthetic active ingredient