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36 , 13201334.e1329 (2024)

Apart from human studies, mice with heterozygous and homozygous mutation in Mthfr C677T still accompany with global DNA hypomethylation, decreased SAM and increased SAH levels 41

Additionally, DHA suppresses the expression of several transcription factors associated with fibrosis, such as lysyl oxidases, collagen subtypes, matrix metalloproteases (MMPs), collagen structure, and tissue inhibitors of metalloproteases (TIMPs)