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1 Introduction Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder that includes loss of tolerance to self-antigen and subsequent activation of autoreactive T and B cells, production of dysregulated cytokines ( The available treatment methods in SLE are chiefly immunosuppressants

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, Functioning as a gas transmitter and signaling molecule, H 2 S mediates cytoprotection against apoptosis through dual mechanisms: direct neutralization of cytotoxic reactive species (e.g., ROS and peroxynitrite) and enhanced expression of endogenous antioxidants (including superoxide dismutase, glutathione, and N-acetylcysteine)