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To assess synergy of the 3-drug combination, the Bliss Independence model was used (39) ( Figures 3CE )

The key findings from this clinical program include significant reductions in body weight and fat mass in treatment groups compared to placebo, preferential loss of abdominal and visceral adipose tissue, no changes in serum IGF-1 levels at any dose tested, no negative effects on glucose metabolism or insulin sensitivity, no significant adverse events related to metabolic or endocrine disruption, and safety profile indistinguishable from placebo for most parameters

In contrast, BPC-157, derived from a naturally occurring protective protein in human gastric juice, has gained fame for its remarkable effects on tendon, ligament, and gut repair

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