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[DOI] [PMC free article] [PubMed] [Google Scholar] 353.Borghammer P, Horsager J, Andersen K, Van Den Berge N, Raunio A, Murayama S, Parkkinen L, Myllykangas L

In bladder cancer cell lines, PHGDH knockdown markedly suppresses proliferative capacity and induces apoptosis

Its potential as a stand-alone treatment or in combination with other peptide hormones will be further explored in phase 2 obesity trials, where long-term safety and efficacy will be evaluated.

TCGA and GEO datasets Transcriptome data of breast cancer (BRCA) cohort from TCGA ( and Gene Expression Omnibus (GEO) dataset (GSE173300, GSE128458, and GSE144378) ( were analyzed