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For example, allopurinol can lead to kidney damage (12), febuxostat can increase the risk of cardiovascular diseases (13), and ibuprofen is associated with symptoms such as dizziness and drowsiness (14)

Gastroenterol Res Pract 2012:615051

148 critically appraised the efficacy of these ventilatory stimulants and concluded that none of the experimental drugs are adequate for therapeutic use in OIRD and all need further study of efficacy and toxicity