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Therefore, the problem that the agents successful in pre-clinical experimental autoimmune encephalitis trials, were either less effective in patients, worsened disease or caused unexpected, severe adverse events (60), may be at least partly solved with the more suited cuprizone model that reflects a toxic experimental model (12)

Reducing severe disability from disease is key to minimizing health and social costs as the population increases

Dugger TW, Sarkar S, Correa-Garhwal SM, Zhernenkov M, Zhang Y, Kolhatkar G, Mohan R , Cruz L, Lubio AD, Ruediger A, Hayashi CY, Uhrich KE, Kisailus DJ