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Studies have demonstrated that serum 1,25(OH)D levels increase in CKD patients following kidney transplantation, indicating that the restoration of functional nephron mass can reestablish vitamin D activation capacity (Figure 2)

In one of these studies, the patient was female [76] and the authors were able to generate an isogenic control line in parallel to the diseased iPSC line, since X chromosomes are known to undergo random X-inactivation and, hence, monoclonal iPSC lines can be derived from somatic cells with an active healthy or diseased X-chromosome

Abstract Impaired redox metabolism is a key contributor to the etiology of many diseases, including primary mitochondrial disorders, cancer, neurodegeneration and aging

J Virol