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Authors information YO, HA, SY and MM were the researchers in the same laboratory and cooperatively carried out the study

Excessive iron accumulation in cells can generate ROS through the Fenton reaction, leading to lipid peroxidation ( GPX4 is a critical regulator in preventing ferroptosis, as it inhibits ferroptosis by catalyzing the reduction of lipid peroxides ( Figure 1 )

GXS: Glyoxalic acid synthetase

Thus, an increase in NRF2 activity, reflected by induction of NRF2 target genes, likely represent an important mechanism mediating the protection seen in GCLM KO mice