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These are well-documented GH effects observed across numerous studies

But the actual numbers differ because tirzepatide and semaglutide come in different concentrations and use different dose ranges

The headline results, as released in the Eli Lilly investor communication and aligned with the study design paper by Giblin and colleagues published in Diabetes, Obesity and Metabolism in 2026, are unusually strong for a Phase 3 obesity trial: Retatrutide 12 mg: mean body-weight reduction of 28.7 percent, roughly 32.3 kg (about 71.2 lbs) from baseline

But when congestion turns into facial pain and pressure that wont go away, we start looking for a sinus infection