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Nor-epinephrine, a major catecholamine that promotes adipocyte lipolysis (83, 84), is released in response to cold stimulation from terminal neurons that innervate fat cells (83) to mediate non-shivering thermogenesis (85-87) through the activation of -adrenergic receptors (-ARs)

All participants followed a calorie-restricted diet (~300 kcal/day deficit)

preparation of certain cations of the invention may occur via a one-pot procedure reported by Venkatesan et al

Further in vitro and ex vivo studies may contribute to our understanding of how mechanistic differences between these two antibodies might translate to better clinical outcomes in MM patients