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Another key difference is tobacco is burned and inhaled as pungent smoke, while e-cigarettes just heat up liquid nicotine to turn it into an odorless vapor

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In Kung SD, Yang SF (eds.)

Because where there are many uncontrolled variables and people are doing other behaviors besides smoking, you dont know if diet or exercise level or weight control might also be having an impact on these people, especially where something like smoking may also impact those behaviors, Cutler explained