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Brand: www.paramparam.eu
SKU: 2016552768
Price: 24.30 USD
Availability: InStock
Rating: 4.4491000000000005 (11 reviews)

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doi: 10.1128/AAC.00037-14 43 HeepM.BrandstatterB.RiegerU.LehnN.RichterE.S

Effects of a central cholinesterase inhibitor on reducing falls in Parkinson disease

This approach inspired other programmes: N-hexanoic-Tyr-D-Arg : enkephalin-derived, protease-resistant, studied for pain N-methyl-Aib inclusions : N-methyl substitutions increase membrane permeability at the cost of partial loss of receptor affinity Beta-peptides and D-amino acids : substitution of natural chiral residues by their D enantiomers, making the peptide invisible to endogenous proteases while (sometimes) preserving function Stapled peptides : hydrocarbon cyclisation, popularised by Verdine (Harvard), stabilises alpha helices and improves cellular penetration These strategies progressively shift the peptide / small molecule frontier