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Variants identified through GWAS hold clinical potential when they demonstrate sufficiently convincing effect sizes, reflected in measures such as the heritability coefficient (i.e., the proportion of phenotypic variance explained by genetics) and the Population Attributable Fraction (PAF, i.e., the proportion of cases in a population attributable to a specific risk factor) [19]

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Why it matters : This process produces methyl groups used for: DNA methylation (gene regulation) Neurotransmitter synthesis (brain health) Detoxification (removing toxins) Heart health (managing homocysteine) What are the most common MTHFR variants

doi: 10.3389/fonc.2019.00352 488 WuHLiCCuiMGuoHChenSDuJEet al