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Contraindications include active or recent cancer, uncontrolled diabetes, severe diabetic retinopathy, and pregnancy

IGF-1 DES: Comparing the Two Major Truncated Analogues IGF-1 DES (des(1-3)-IGF-1) lacks the first three N-terminal amino acids of native IGF-1

A 2020 review in Diabetes Care noted that "the hypoglycaemic effect of IGF-1 has been exploited therapeutically in rare forms of insulin-receptor-defect syndromes, but the risk-benefit calculation differs fundamentally from use in euglycaemic individuals" [20]

In this review, we attempt to crystallize these concepts and analyze the current evidence supporting the efficacy of glutathione as an inhibitor of melanization