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Older adults, vegans, individuals with gastrointestinal conditions, and those taking metformin or proton pump inhibitors often require higher doses or supplementation

And I think that point has to do with the intermittent challenging of yourself and whether that is through temperature changes, like cold or heat, or through other types of stressors, like physical activity or perhaps even dietary compounds that are found in plants, these are things like polyphenols or flavanols

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Cognitive and mood benefits often appear within the first month of regular supplementation