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Discussion Significantly increased cortisol concentrations in the serum of the studied men after 8 days of water-only fasting and maximum physical exercise indicate the stimulation of a strong stress reaction, which was activated mainly by the fasting intervention

UV exposure induces the production of ROS, which subsequently activate the NF-B and MAPK signaling pathways, leading to increased transcription of pro-inflammatory cytokines (IL-1, TNF-, IL-6 and COX-2) and MMP-1, both of which contribute to inflammation and collagen degradation

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