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Running on time: the role of circadian clocks in the musculoskeletal system

Guan Z, Stephan BCM, Donini LM, Prado CM, Sim M, Siervo M

Additionally, the cost-effectiveness of combining vascular disruption and normalization therapies remains underexplored and should be a priority in future studies to ensure that these strategies can be implemented in clinical practice without undue financial burden

When copper accumulates excessively or is improperly transported, the disruption of copper homeostasis causes cellular toxicity when copper concentrations in cells exceed the threshold that homeostatic mechanisms can tolerate (123)