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In addition, B12 deficiency-associated fatigue is often accompanied by other symptoms such as numbness and tingling, cognitive impairment (memory and concentration problems), mood swings (depression), skin changes (pale skin), shortness of breath, or fast heart rate

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highlighted the impact of Cd38 gene deletion on lysosome function and autophagic flux, resulted in the formation and activation of the Nlrp3 inflammasome and subsequent thickening of coronary arterial walls [29]

doi: 10.3389/fonc.2022.894744 Received 12 March 2022 Accepted 29 April 2022 Published 09 June 2022 Volume 12 - 2022 Edited by Ubaldo Emilio Martinez-Outschoorn, Thomas Jefferson University, United States Reviewed by Fumiaki Uchiumi, Tokyo University of Science, Japan