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Under heat stress stimulation in both in vivo mouse models and in vitro cell experiments, the transport of p53 protein from the nucleus to the cytoplasm increases significantly, where it binds to Parkin protein, reducing Parkin's translocation from the cytoplasm to mitochondria

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7 Tumor-associated neutrophils (TANs) are neutrophils present in tumors, typically displaying tumor-promoting properties

at this point only a few early stage clinical trials are taking place worldwide