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Therapeutic AAV9-mediated suppression of mutant SOD1 slows disease progression and extends survival in models of inherited ALS

The developed micelles were nontoxic, had a rapid accumulation and distribution at the tumor site, and had high DOX release rates at GSH concentrations of 1 mg mL 1 , while also being highly toxic to the A549 human non-small cell lung cancer cell line [59]

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Thornes rationale is that sustained delivery keeps glutathione levels more stable throughout the day rather than creating a short spike followed by a trough