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Poly-ubiquitin chains are particularly important, as they often label target proteins to be sent to the proteasome for degradation, which is a major mechanism by which cells remove unwanted or damaged proteins

Passage of bacteria and their products from the gut lumen to the bloodstream and liver and spleen is known as intestinal bacterial translocation

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These results warrant future research to study the effect of zinc and selenium supplementation at a cellular level, with a higher number of individuals per group and validation experiments to correlate gene expression with the presence of the functional protein