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Res 35 , 17491758 (2011)

Production of GSH occurs by two mechanisms, de novo synthesis and recycling of GSSG

But the leaks (oxidative stress, inflammation, mitochondrial injury) usually start years earlier

[6] A second study by Ionescu and Frohman gave a single injection to healthy men and showed that GH secretion rose driven mostly by a marked increase in trough GH while preserving the normal pulsatile pattern, with a corresponding rise in IGF-1