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Although the study did not meet its primary endpoint (placebo-corrected change in the overall mFARS score at 72 weeks), vatiquinone treatment demonstrated nominally significant and clinically meaningful benefits in specific disease subscales, most notably preserving upright stability and reducing fatigue, with an excellent safety profile

The vCAFs can produce several angiogenesis factors, such as VEGF, FGF, PDGF, and osteopontin to promote the vessel formation by recruiting myeloid cells and accelerate angiogenesis by attracting vascular endothelial cells and recruiting monocytes (94, 95)

The general form, applicable to all the different metalcoordinated forms of SOD, can be written as follows: M (n+1)+ SOD + O 2 M n+ SOD + O 2 M n+ SOD + O 2 + 2H + M (n+1)+ SOD + H 2 O 2 The reactions by which SODcatalyzed dismutation of superoxide for Cu,Zn SOD can be written as follows: Cu 2+ SOD + O 2 Cu + SOD + O 2 (reduction of copper

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