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In addition to Se as the main regulator of GPx1 expression, the factors associating the selenocysteine insertion sequence (SECIS), adenosine [33], c-Abl and Arg tyrosine kinase receptors, and epidermal growth factor influence gene expression of GPx1 and affect the functional coordination between GPx1 and other selenoproteins or antioxidant enzymes in various metabolic circumstances

There, it stabilizes protein complexes and facilitates oxidative phosphorylation, and it also regulates the release of cytochrome c from mitochondria to launch an apoptotic cascade