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Importantly, most exogenous MSU injection models primarily reproduce acute inflammatory flares rather than the spontaneous and natural course of human gout (69), whereas hyperuricemia models mainly reflect the metabolic basis of disease initiation and do not directly correspond to typical gouty arthritis attacks

The markers of oxidative stress and activity of the antioxidant system in the blood of elderly patients with essential arterial hypertension

Interestingly, GFR remained increased even 14 days after cessation of rhIGF-1 therapy compared to placebo-treated controls, suggesting that rhIGF-1 resulted in renal hypertrophy, since the hemodynamic effects should have worn off within 14 days of cessation

Insulin resistance during puberty and pregnancy is, in part, attributed to increased concentrations of circulating GH