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Human and mouse gliomas exhibit high rates of glucose catabolism, and use glucose to synthesize glutamine through glutamate-ammonia ligase (GLUL), which in turn promotes nucleotide biosynthesis via the pentose phosphate pathway independently of circulating glutamine [189,190]

A recent study [14] of children ages 1-5 years found lower levels of lead, cadmium, and arsenic in the hair of children with autism, suggesting a decreased ability to excrete those metals