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The most important characteristics of these neuralgias include the fact that pain is circumscribed to the area innervated by the affected nerve and is usually continuous (except in infratrochlear neuralgia, which tends to be paroxysmal), the presence of hypersensitivity at the emergence or along the trajectory of the nerve, the appearance of clinical or subclinical signs of sensory dysfunction in the affected territory, and the fact that pain is completely and transiently relieved by blocking the specific nerve.2630 Neuroimaging With a view to ruling out secondary causes, brain MRI studies are advisable in all patients with a clinical diagnosis of TN.31 The use of 3D reconstruction techniques, rather than the classical 2D sequences, enables optimal anatomical assessment of the nerve

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Advanced delivery systems, including encapsulation in liposomes or conjugation with lipid-based carriers, are often employed to enhance penetration and protect peptides from enzymatic degradation, thereby amplifying their therapeutic efficacy

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