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10.1016/j.fitote.2014.05.010 207 WangL.XuN.ZhangJ.ZhaoH.LinL.JiaS.et al (2015)

Biochemical analyses AChE activity AChE activity in the hippocampus and cerebral cortex homogenates was determined using a Biochain kit (Biochain, CA), according to the manufacturers protocol as previously described 34

But the major limitation of the use of flavonoids is the adverse effects associated with their consumption in high doses, including necroptosis, apoptosis, cardiac dysfunction, and neurotoxic side effect (Satari et al., 2021)

CMS121 has completed IND-enabling studies, and J147 has entered Phase 1 clinical trials, underscoring their pathway-driven therapeutic promise (Maher et al., 2020