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OCs, which are fundamental to bone remodeling, are affected by CD38 inhibition, which not only inhibits bone resorption [41] but also restores T-cell function, thereby averting the progression of bone disease [42]

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CD38 is a druggable target in the therapy of human cancers

In relapsed or refractory myeloma (R/R MM) patients, the CD38 expression levels are relatively high in NK cells, regulatory B cells (Bregs), Tregs and myeloid-derived suppressor cells (MDSCs) compared with CD8 + and CD4 + T cells, indicating that CD38 is involved in providing the immunosuppressive environment for tumor growth [19]