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FDA Commissioner Marty Makary stated that the agency was making the evidence known but emphasized that the choice still belongs with parents. So, it suggests that many individuals might avoid APAP during pregnancy as a precautionary measure

If there is no clear clinical improvement within 2-3 weeks, second-line options such as RTX or CP should be initiated immediately

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However, not all individuals produce UroA efficiently owing to variations in gut microbiome composition, which has led to the development of direct supplementation strategies to achieve consistent levels across different populations (Reference Singh, DAmico and Andreux11)