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A handful of other genes, including ODZ4 , coding for cell surface proteins involved in signaling and neuronal path finding, NCAN , a brain-expressed extracellular matrix glycoprotein (rodents with altered NCAN gene function show manic-like behaviors) and ANK3 , a gene involved in localization of sodium channels, have had replicated GWAS support (20, 33, 34, 37, 38)

They produce cytokines such as TGF-beta, IL-10, and IL-35, which inhibit T cells, leading to suppressed actions of Th1, Th2, and Th17 type T cells