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This spike in circulating cortisol can trigger the gut-brain axis via the vagus nerve, signaling the enteric nervous system to accelerate motility and cause sudden bathroom urgency

In vitro studies indicate that exposure to PS-MPs triggers NF-B pathway activation in microglia, resulting in an overproduction of IL-1, TNF-, and nitric oxide (NO) 37

[DOI] [PMC free article] [PubMed] [Google Scholar] 151.Mumtaz G.R., Weiss H.A., Thomas S.L., Riome S., Setayesh H., Riedner G., Semini I., Tawil O., Akala F.A., Wilson D., et al

One case, reported by Bleifuss et al., was managed with standard ARDS care, including inhaled epoprostenol, bronchodilators, intravenous dexamethasone, and prone positioning ( TABLE 2 Published cases in chloride inhalational injury