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10.1016/j.jad.2006.08.023 128 MorrisC

This contributes to pain reduction in many injury protocols

Under homeostatic conditions of self-renewal but also in response to injury, crypt base columnar cells (CBCs) expressing the leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) feed the transit amplifying zone of the epithelium, and progenitor cells finally differentiate into mature secretory (e.g., Paneth cells, goblet cells, enteroendocrine cells) and absorptive cells (columnar shaped enterocytes) 29