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Studies have shown a strong association between high levels of SEMA4D and increased counts of M2 macrophages in both primary tumors and ascites, further linking SEMA4D to the aggressive behavior of EOC and suggesting its potential as a target for prognostic and therapeutic strategies (145)

Front Immunol (2023) 14:1107670

Methods: The study is nested in the MAUCO cohort, including 349 participants of the MAUCO+ lifestyle intervention aimed at preventing NAFLD and cardiovascular diseases, which included participants aged 45-60 years, with varying degrees of fatty liver