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Nascimento RDPD et al (2020) Ulcerative colitis: Gut microbiota, immunopathogenesis and application of natural products in animal models

Specifically, 47 integrin regulates the localization of lymphocytes to the gut mucosa by binding to the gut-specific cell adhesion molecule mucosal addressin cell adhesion molecule-1 (MAdCAM-1), promoting the accumulation of immune cells at the site of inflammation, thereby exacerbating the intestinal inflammatory response [303, 304]