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205 Mitonuclear feedback is achieved through bidirectional communication: anterograde signaling, where information flows from the nucleus to the mitochondria, and retrograde signaling (RTG), where the mitochondria transmit signals to the nucleus in response to mitochondrial dysfunction

This approach reduced ACSL4 protein levels, upregulated GPX4 levels, and inhibited ferroptosis in DRG and spinal cord cells, effectively alleviating inflammatory pain symptoms [19]

This seminal paper in remyelination biology establishes that remyelination can restore efficient impulse conduction to demyelinated axons

Biochem Biophys Res Commun 2002