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Retrieved October 6, 2025

GRP receptor blockade may serve as a broad spectrum of anti-inflammatory therapy for asthma [58,59], since reduced neutrophilic inflammation and cytokine production triggered by ozone were reduced with GRP blocking agent or antibody [53]

Repeated supratherapeutic dosing, alcohol misuse, malnutrition, low body weight, and prolonged fasting significantly increase risk a fact highlighted in regulatory safety reviews by the MHRA and FDA