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Description

65 mg/kg + BBM [1, 5, and 15 mg/kg])

The resulting metabolic disturbances trigger the production of adipocin, especially TNF-, IL-6, and Monocyte Chemoattractant Protein-1 (MCP-1, also known as CCL2), to induce inflammatory mediators

Liu et al., 2018), likely due to reduced appetite and stress

1,13,14 Metformin, an insulin-sensitizing agent, is a second-line treatment option for metabolic concerns when oral contraceptives and lifestyle changes do not provide satisfactory results