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For illustration, it is challenging for cell models to replicate the intact BRB, a highly specialized structure composed of RPE cells, RCECs, and tight junctions, which restricts the entry of Fe + and limits the infiltration of pro-oxidative factors (95)

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Complex role of hemoglobin and hemoglobin-haptoglobin binding proteins in Haemophilus influenzae virulence in the infant rat model of invasive infection